xkcd - A webcomic of romance, sarcasm, math, and language - By Randall Munroe
New comic every M-W-F. Always weird, often roll-on-the-floor funny. And seriously, how many people do you know who could get a reference to Ubuntu Linux AND Pokemon into a one panel comic?
And if you’re into webcomics, don’t miss Goats and Unshelved, either.